viernes, octubre 08, 2010

Article on synbio in Africa

Synthetic biology in Africa: time to pay attention

Gareth Jones and Mariam Mayet

2010-10-07, Issue 499

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Synthetic biology – the design and engineering of biological components that can be used to construct a variety of biological systems – is a hot scientific topic. But with enormous implications for human health, Gareth Jones and Mariam Mayet ask when the very real ethical concerns associated with the technology will be debated.
‘…[synthetic biology] is broadly understood as the deliberate design of novel biological systems and organisms that draws on principles elucidated by biologists, chemists, physicists and engineers…in essence it is about redesigning life.’ [1]

The emerging field of synthetic biology has been making waves in the global scientific community recently. Earlier this year, Craig Venter, the doyen of the genomics world, claimed that his company had created the world’s first self-reproducing organism.

Scientists have proclaimed that the discipline is on the cusp of opening doors to almost limitless supplies of agro-fuels and pharmaceutical compounds. The ethical implications of this new technology are considerable, as not only will it ultimately offer the potential to create biological systems and organisms that do not occur in nature, but scientists have already been able to synthesise several lethal human pathogens and viruses.[2] However, according to an EU High Level Expert Group (HLEG) on synthetic biology, ‘it seems likely that we do not as yet possess a conceptual ethical framework that can provide a common context for such debates.’[3]

As definitions of synthetic biology depend upon the scientific approach taken or the final application of a given project, a standard classification has remained elusive. However, it is generally accepted that the discipline utilises principles drawn from multi-disciplinary fields, including nano-technology, biology, physics, chemistry and genetic engineering, to design and engineer biological components that can be used interchangeably to construct a variety of biological systems. These systems could be constructed for a variety of uses, ranging from the production of pharmaceuticals, chemicals, hydrocarbons and food.[4]

Funding of synthetic biology

Research carried out by the Synthetic Biology Project [5] has revealed that there are currently over 180 organisations in the United States and a further 50 in Europe that are involved in synthetic biology research, development and commercialisation. The current annual research market for synthetic biology is worth an estimated US$600 million, a figure that could potentially exceed US$3.5 billion over the next decade. Other projections from the industry go even further, with one postulating that as much as 20 per cent of the $1.8 trillion global chemical industry could be dependent on synthetic biology by 2015.[6]

Since 2005, research related to synthetic biology has received approximately US$430 million from the US government, while the European Union (EU) and the governments of Germany, the Netherlands and the United Kingdom have spent in the region of US$160 million.

The United States Department of Energy (DOE) is by far the biggest individual source of research funds, with conservative estimates putting its largesse at US$350 million over the period (which could be as high as US$700 million). The US Department of Defence is also reported to have committed US$20 million of its gargantuan budget for 2010/11 towards synthetic biology research, though further information is unavailable to the public.

Synthetic biology was earmarked as a priority research area in the EU back in 2003 and US$53 million in funding has been approved since then. The UK government is estimated to have spent between US$30 million and US$53 million since 2005. In 2008, three Dutch universities (Delft University of Technology, University of Gronigen and the Eindhoven University of Technology) announced an investment plan of US$90 million over the next five to ten years.[7]

Just four per cent of US research spending since 2005 has been devoted to the ethical, legal and social implications of synthetic biology. In Europe the figure is even lower, a paltry two per cent. Most disturbingly, not a single research grant dedicated to the risk assessment of synthetic biology can be identified.[8]

Private funding for synthetic biology research is directed overwhelmingly towards agro-fuel applications, with big-oil leading the way. In 2009, Exxon Mobil, in its first major investment in agro-fuels, entered into a US$600 million partnership with Synthetic Genomics to develop transportation fuels from algae.[9] In 2007, BP announced a US$500 million research agreement with the University of California, Berkeley (UCB), to develop synthetic agro-fuels.[10] Amyris biotechnologies, the company established in 2003 by Professor Jay Keasling, the principle investigator on the UCB’s artemisinin project, recruited the former head of US fuels at BP to be its first CEO. Its largest stockholder is the French oil and gas giant Total.

This flood of capital into the field has, in the view of at least one professor of biomedical engineering, diverted skills and focus from areas where the discipline could potentially benefit the wider public.[11] The parallels with the genetic engineering of food crops could not be more striking. For the last decade highly lucrative GM commodities such as maize and soy (that are predominantly used to feed the animals raised in industrial agricutural production, which in turn feed the global minority who can afford that meat) have been bringing in record profits for the global agro-seed-and chemical complex. Over the same period the deluge of ‘benefits’ that were set to emancipate the wretched of the earth from hunger and poverty have failed to materialise.


Implications for Africa

As far as we know, there are no national, regional nor international biosafety rules in place to regulate synthetic biology in the world today, despite its ability to have far reaching implications for humanity and the natural world. Nevertheless, the issue is being discussed at international fora, including the Convention on Biological Diversity. At the 14th meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA14), synthetic biology was specifically debated. The report of SBSTTA 14 [29] contains several references to synthetic biology, in square brackets, including a de facto moratorium on the release of synthetic life forms.[30] However, square brackets means that it has not achieved unanimous agreement and will be further discussed at the 10th ministerial meeting of the UN Convention's Conference of the Parties (COP 10) that will take place in Nagoya, Japan between 18 and 29 October 2010.

Although the issue is on the international agenda, it is doubtful whether the proposed moratorium will survive in the face of the huge financial and strategic interests at stake. At the very least, those concerned with the implications of this technology for society and the environment may be able to obtain some form of rules and procedures to govern the use of the technology. Even this route will be highly contested and bitterly fought by those set to benefit the most.

The potential impact of synthetic biology on the African continent requires extensive public debate in an open and transparent manner. Valuable lessons must be heeded from prior experiences where exogenous technology has been imposed on the continent, without there being enough public engagement and adequate local authority and capacity to regulate it.

For the most appropriate example in this instance, one need look no further than what has been happening with biotechnology using genetic engineering techniques in Africa.

Currently, only three countries on the African continent commercially produce genetically modified crops: Burkina Faso, Egypt and South Africa.[31] This has not stopped a deluge of ‘capacity building’ initiatives, funded in the main by the biotech industry and their PR shock troops at organisations such as USAID and the Gates Foundation, throughout the continent.

While ostensibly the modus operandi of these initiatives is to help Africa to feed itself, in the absence of domestic biotechnology expertise it also conveniently provides the opportunity for the shaping of the biosafety discourse to suit the technologies’ developers and others that stand to benefit from the use of the technology.[32] Further, the gains made at the multilateral level for the safe governance of biotechnology, through the Cartagena Protocol on Biosafety, are being undermined by efforts to ‘harmonise’ biosafety legislation across Africa through its regional economic communities (RECs). For example, from a recent draft GMO policy document from the Common Market for Eastern and Southern Africa (COMESA), it was patently clear that the architects of the policy had close ties to an industry that would benefit enormously should such policies come to fruition.[33]


Synthetic biology offers yet more currency to the hubris that man is ‘master’ of his environment. Yet this mastery comes with a heavy responsibility. The potential to produce almost limitless amounts of cheap medicine and clean fuels must be tempered by the fact that the technology is still in its infancy, and that its real consequences cannot yet be predicted with any great certainty. As is the case with food, abundance alone does not guarantee availability. Will the provision of anti-malarial drugs be more effective in a centralised system, where a few companies exert exclusive control, or in a more nuanced fashion, where locally source material can be quickly and efficiently processed and distributed to those in most need?

To date the real money in synthetic biology appears to be following its energy potential, with the world’s largest oil companies having already sunk hundreds of millions of dollars into the field. South Africa appears to be banking on the technology as a means to cement its place inside this global event. This unbridled enthusiasm, however, has taken place largely beyond public scrutiny or awareness of what is really and truly at stake.


* Gareth Jones is a researcher at the African Center for Biosafety. Mariam Mayet is the director of the African Center for Biosafety.
* Please send comments to or comment online at Pambazuka News.

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